Peyronie’s Disease

Peyronie’s disease is caused by progressive fibrosis (plaque) of the normally elastic tunica albuginea (the lining of the erectile tubes within the penis) resulting in curvature or other deformities of the erect penis. There may be pain initially, or it may be the curvature or scar tissue that is first noticed. There is a genetic predisposition. The incidence of PD has been found to be as high as 9%.

PD is thought to be an overresponse to minor trauma of the penis which usually goes unnoticed. If the curvature is excessive, vaginal penetration can be difficult, partners may suffer pain resulting in significant emotional distress to both.

For diagnosis, normally a history and examination is sufficient but at times a penile ultrasound or penile Doppler ultrasound may be indicated.

At Perth Men’s Health the initial treatment involves medication to reduce inflammation in the plaque and remodelling of the plaque using a Vacuum Constriction Device in a structured program. Bringing in a photo of the erect penis (from the top and side) is useful as a baseline.

One Australian study found that 12% of men had recovery over 12 months.

A new treatment (Xiaflex injections) with injections into the plaque to dissolve the scar tissue shows promise.

In some cases surgery will be required to straighten the penis and in extreme instances, a penile implant is inserted.